and Brain Sciences
Dr. Andrea Hohmann
Linda and Jack Gill Chair of Neuroscience
hohmanna [at] indiana.edu
office: MSB2 220 | (812)856-0672
lab: MSB2 254 | (812)856-3523
Mechanisms of pain, novel pain therapies
- 1996 Ph.D. Brown University
- 1993 Sc.M. Brown University
- 1988 B.Sc. Brown University
- Biology & behavior
Functional roles of the brain's own cannabis-like (endocannabinoid) system in the nervous system; mechanisms of pain and analgesia; mechanisms of action of drugs of abuse; novel therapeutics
- My research has focused on understanding pain modulation from a neurochemical perspective. The discovery of cannabinoid receptors and identification of brain constituents that act at these receptors established the existence of an endogenous cannabis-like (endocannabinoid) transmitter system. My research has identified functional roles of the endocannabinoid system in the nervous system and mapped it's distribution in sensory pathways. My research has identified enzymes implicated in endocannabinoid deactivation as novel therapeutic targets. My laboratory strives to maximize the therapeutic potential of endocannabinoid signaling systems while minimizing unwanted central nervous system side-effects (e.g. psychoactivity and addiction). My research program combines behavioral, drug self-administration, neuroanatomical, neurophysiological and molecular approaches to study cannabinoid mechanisms for suppression of pain and stress responsiveness.
Please search for "A. G. Hohmann" on PubMed to view recent publications from this investigator.
Nackley, A.G., Makriyannis, A. and Hohmann, A.G. (2003) Selective activation of cannabinoid CB2 receptors suppresses spinal Fos protein expression and pain behavior in a rat model of inflammation. Neuroscience 119: 747-757.
Nackley, A.G., Zvonok, A.M., Makriyannis, A., and Hohmann, A.G. (2004) Activation of cannabinoid CB2 receptors suppresses C-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation. Journal of Neurophysiology 92: 3562-3574.
Hohmann, A.G., Suplita II, R.L., Bolton, N.M., Neely, M.H., Fegley, D., Mangieri, R., Krey, J.F., Walker, J.M., Holmes, P.V., Crystal, J.D., Duranti, A., Tontini, M., Tarzia G. and Piomelli, D. (2005) An endocannabinoid mechanism for stress-induced analgesia. Nature 435: 1108-1112.
Suplita II, R.L., Farthing, J., Gutierrez, T. and Hohmann, A.G. (2005) Inhibition of fatty-acid amide hydrolase enhances cannabinoid stress-induced analgesia: Sites-of-action in the dorsolateral periaqueductal gray and rostral ventromedial medulla. Neuropharmacology 49:1201-1209.
Moise, A.M., Eisenstein, S.A., Astarita, G., Piomelli, D. and Hohmann, A.G. (2008) An endocannabinoid signaling system modulates anxiety-like behavior in male Syrian hamsters. Psychopharmacology 200: 333-346.
Rahn, E.J., Zvonok, A.M., Thakur, G., Khanolkar, A.D. Makriyannis, A. and Hohmann, A.G. (2008) Selective activation of cannabinoid CB2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent paclitaxel in rats. Journal of Pharmacology and Experimental Therapeutics 327: 584-591.
Rahn, E.J. and Hohmann, A.G. (2009) Cannabinoids as pharmacotherapies for neuropathic pain: from the bench to the bedside. Neurotherapeutics 6: 713-737.
Guindon, J. and Hohmann, A.G. (2009) The endocannabinoid system and pain. CNS & Neurological Disorders-Drug Target 8 (6) 403-421.
Eisenstein, S.A., Clapper, J., Holmes, P.V., Piomelli, D. and Hohmann, A.G. (2010) A role for 2-arachidonoylglycerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy. Pharmacological Research 61: 419-429.
Sciolino, N.R., Bortolato, M., Eisenstein, S.A., Fu, J., Oveisi, F., Hohmann, A.G. and Piomelli, D. (2010) Social isolation and chronic handling alter endocannabinoid signaling and behavioral reactivity to context in adult rats. Neuroscience (2010) 168: 371-386.