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Indiana University Bloomington

Josée Guindon

Dr. Josée Guindon

Assistant Scientist

 

jguindon [at] indiana.edu

office: MSBII 208

lab: MSBII 254

 

Behavioral pharmacology, animal pain models, modulation of pain pathways, animal pain models, kidney protective mechanism

Educational Background

  • 2007 - Ph.D. in pharmacology, Université de Montréal
  • 2002 - M.Sc. Biomedical Sciences, Université de Montréal
  • 2000 - D.V.M., Université de Montréal

Areas of Study

  • Pharmacology
  • Neuroscience
  • Behavioral pain models

Research Statement

The focus of my research is to investigate and to understand the different mechanism involved in pain pathways. How to modulate pain by using physiological processes as well as reference compounds and endocannabinoid modulators is one of my main interest. The use of different pain models such as acute, inflammatory and neuropathic pain models and the combination of known treatment with cannabinoid compounds to alleviate pain is another area of my expertise. I have also recently begin to investigate the physiological processes involved in kidney protection following chemotherapy treatment.

Representative Publications

    Guindon, J. & Hohmann, A.G. (2013) Use of sodium bicarbonate to promote weight gain, maintain body temperature and prevent mortality in rodents receiving the chemotherapeutic agent cisplatin. Neuroscience Letters, 544, 41-46.

    Guindon J., Lai, Y., Takacs, S.M., Bradshaw, H.B., Hohmann, A.G. (2012) Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: Effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment. Pharmacological Research, 67, 94-109.

    Deng, L., Guindon, J., Vemuri, V.K., Thakur, G.A., White, F.A., Makriyannis, A., Hohmann, A.G. (2012) The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CB2 receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced neuropathy. Molecular Pain, 8, 71.

    Guindon, J. (2012) Nabilone in inflammatory pain: to be or not to be. Clinical and Experimental Pharmacology and Physiology, 39, 327-328.

    Guindon, J., Hohmann, A.G. (2011) The endocannabinoid system and cancer: Therapeutic Implications. British Journal of Pharmacology, 163, 1447-1463.

    Guindon, J., Guijarro, A. A., Piomelli, D., Hohmann, A.G. (2011) Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain: a comparative analysis. British Journal of Pharmacology, 163, 1464-1478.

    Spradley, J.M., Guindon, J., Hohmann, A.G. (2010) Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differientially suppress capsaicin-induced behavioural sensitization through peripheral endocannabinoid mechanisms. Pharmacological Research, 62, 249-258.

    Guindon, J., Hohmann, A.G. (2009) The endocannabinoid system and pain. CNS & Neurological Disorders-Drug Target, 8, 403-421.

    Desroches, J., Guindon, J., Lambert, C., Beaulieu, P. (2008) Modulation of the antinociceptive effects of 2-arachidonoyl glycerol by peripherally administered FAAH and MGL inhibitors in a model of neuropathic pain. British Journal of Pharmacology, 155, 913-924.

    Guindon, J., Hohmann, A.G. (2008) A physiological role for endocannabinoid-derived products of cyclooxygenase-2-mediated oxidative metabolism. British Journal of Pharmacology, 153, 1341-1343.

    Guindon, J., Hohmann, A.G. (2008) Cannabinoid CB2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain. British Journal of Pharmacology, 153, 319-334.

    Dani, M., Guindon, J., Lambert, C., Beaulieu, P. (2007) The local antinociceptive effects of paracetamol in neuropathic pain are mediated by cannabinoid receptors. European Journal of Pharmacology, 573, 214-215.

    Guindon, J., Walczak, J.S., Beaulieu, P. (2007) Recent Advances in the Pharmacological Management of Pain. Drugs, 67, 2121-2133.

    Guindon, J., Desroches, J., Dani, M., Beaulieu, P. (2007) Pre-emptive antinociceptive effects of a synthetic cannabinoid in a model of neuropathic pain. European Journal of Pharmacology, 568, 173-176.

    Guindon, J., Desroches, J., Beaulieu, P. (2007) The antinociceptive effects of intraplantar injections of 2-arachidonoyl glycerol are mediated by cannabinoid CB2 receptors. British Journal of Pharmacology, 150, 693-701.

    Guindon. J., Lo Verme, J., Piomelli, D., Beaulieu, P. (2007) The antinociceptive effects of local injections of propofol in rats are mediated in part by cannabinoid CB1 and CB2 receptors. Anesthesia & Analgesia, 104, 1563-1569.

    Guindon, J., Lo Verme, J., De Léan, A., Piomelli, D., Beaulieu, P. (2006) Synergistic antinociceptive effects of anandamide, an endocannabinoid, and nonsteroidal anti-inflammatory drugs in peripheral tissue: a role for endogenous fatty-acid ethanolamides? European Journal of Pharmacology, 550, 68-77.

    Guindon, J. & Beaulieu, P. (2006) Antihyperalgesic effects of local injections of anandamide, ibuprofen, rofecoxib and their combinations in a model of neuropathic pain. Neuropharmacology, 50, 814-823.

    Guindon, J., De Léan, A., Beaulieu, P. (2006) Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain. Pain, 121, 85-93.